Bone morphogenetic protein 5

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Bone morphogenetic protein 5
Identifiers
Symbols BMP5 ; MGC34244
External IDs OMIM112265 MGI88181 HomoloGene22412 GeneCards: BMP5 Gene
RNA expression pattern
PBB GE BMP5 205431 s at tn.png
PBB GE BMP5 205430 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 653 12160
Ensembl ENSG00000112175 ENSMUSG00000032179
UniProt P22003 P49003
RefSeq (mRNA) NM_021073 NM_007555
RefSeq (protein) NP_066551 NP_031581
Location (UCSC) Chr 6:
55.62 – 55.74 Mb
Chr 9:
75.78 – 75.9 Mb
PubMed search [1] [2]

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[1][2][3]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[3]

References[edit]

  1. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904. 
  2. ^ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neurosci 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864. 
  3. ^ a b "Entrez Gene: BMP5 bone morphogenetic protein 5". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.