Bone morphogenetic protein 8b

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Bone morphogenetic protein 8b
Identifiers
Symbols BMP8B ; BMP8; OP2
External IDs OMIM602284 HomoloGene74865 GeneCards: BMP8B Gene
RNA expression pattern
PBB GE BMP8B 207865 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 656 12163
Ensembl ENSG00000116985 ENSMUSG00000032726
UniProt P34820 P34821
RefSeq (mRNA) NM_001720 NM_001256019
RefSeq (protein) NP_001711 NP_001242948
Location (UCSC) Chr 1:
40.22 – 40.25 Mb
Chr 4:
123.31 – 123.34 Mb
PubMed search [1] [2]

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.[1][2][3]

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.[3]

References[edit]

  1. ^ Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem 267 (35): 25220–7. PMID 1460021. 
  2. ^ DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics 40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID 9070944. 
  3. ^ a b "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.