"Bookworm, Run!" is a science fiction short story written by Vernor Vinge; it is Vinge's second published work of fiction. It appeared in Analog Science Fiction Science Fact in 1966, and was reprinted in True Names... and Other Dangers in 1987, and in The Collected Stories of Vernor Vinge.
As with many of Vinge's later works, "Bookworm, Run!" deals with intelligence amplification: Norman Simmons, the bookworm of the title, is a surgically altered chimpanzee with human-equivalent intelligence.
As part of an experiment, Norman's brain has been given a wireless link to an enormous database. By accident, he is given access to the United States Government's main database. Seeking knowledge for its own sake, Norman asks for all the data stored within; one of the first facts he consciously realizes from his direct-brain download is that, by accessing classified data, he has just committed a federal crime with severe penalties.
Norman uses his new knowledge of the layout of the facility he inhabits to escape, and then correlates several seemingly unrelated facts to (correctly) deduce not only that there must be Soviet spies living in town, but who they are; he makes his way to the agents, hoping that they will help him reach the Canadian border and escape the US Army.
As Norman nears the limit of the wireless link's range, he and the agents are captured; the Soviets' memories are surgically read and erased. Within the agents' memories is the revelation that the Soviet Union has performed similar intelligence-amplification experiments, but on a dog instead of a chimpanzee, foreshadowing a new arms race.
Vinge has said  that the "important" sequel to Bookworm would have featured the first human with amplified intelligence; however, when he attempted to sell such a story to John W. Campbell, Campbell rejected it with the explanation "You can't write this story. Neither can anyone else."