The music video starts with the lead singer (Dan Layus) playing a piano on a beach with the sea at low tide initially, later showing numerous other abandoned pianos on the beach. As the video progresses, other band members appear. Soon after, high tide comes up and the entire band continues to play as they are submerged in water over and over. Band members have been shown to be struggling to keep up with their musical instruments, but they do not seem to give up playing even in such adverse conditions. The video ends showing all musical instruments left shattered by the sea waves.
In the third episode of the first season of The Big Bang Theory, "The Fuzzy Boots Corollary", Leonard walks into his apartment singing the song, remarking "God, that's a good song," to which his roommate Sheldon replies, "If you're compiling a mix CD for a double suicide." "Boston" was used in the third season finale of One Tree Hill, "The Show Must Go On", when Brooke Davis and Lucas Scott have their last dance as a couple. It was also featured in Scrubs, in the 19th episode of the fifth season, "His Story 3" and in "Here Comes the Judge", the 15th episode of season one of Shark. It's also heard in the film A Warrior's Heart.