Brain-specific angiogenesis inhibitor 1

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Brain-specific angiogenesis inhibitor 1
Identifiers
Symbols BAI1 ; GDAIF
External IDs OMIM602682 MGI1933736 HomoloGene1287 IUPHAR: BAI1 GeneCards: BAI1 Gene
RNA expression pattern
PBB GE BAI1 206083 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 575 107831
Ensembl ENSG00000181790 ENSMUSG00000034730
UniProt O14514 Q3UHD1
RefSeq (mRNA) NM_001702 NM_174991
RefSeq (protein) NP_001693 NP_778156
Location (UCSC) Chr 8:
143.53 – 143.63 Mb
Chr 15:
74.52 – 74.59 Mb
PubMed search [1] [2]

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]

Function[edit]

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[2]

Interactions[edit]

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]

References[edit]

  1. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023. 
  2. ^ a b "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1". 
  3. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  4. ^ Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (October 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924. 
  5. ^ Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (June 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.