Brain-specific angiogenesis inhibitor 3

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Brain-specific angiogenesis inhibitor 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BAI3 ; KIAA0550; MGC133100
External IDs OMIM602684 MGI2441837 HomoloGene1289 IUPHAR: BAI3 GeneCards: BAI3 Gene
Orthologs
Species Human Mouse
Entrez 577 210933
Ensembl ENSG00000135298 ENSMUSG00000033569
UniProt O60242 Q80ZF8
RefSeq (mRNA) NM_001704 NM_175642
RefSeq (protein) NP_001695 NP_783573
Location (UCSC) Chr 6:
68.64 – 69.39 Mb
Chr 1:
25.07 – 25.83 Mb
PubMed search [1] [2]

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[1][2]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[3] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shwon to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.


References[edit]

  1. ^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1-2): 103–8. doi:10.1159/000134693. PMID 9533023. 
  2. ^ a b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3". 
  3. ^ Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.