About the making of the album, Dee Dee wrote in his autobiography, Lobotomy: Surviving the Ramones:
It was tough recording the Brain Drain album because everyone took their shit out on me. I dreaded being around them. It drove me away — I didn't even end up playing on the album. Everybody in the band had problems; girlfriend problems, money problems, mental problems.
In the music videos for "Pet Sematary", Dee Dee Ramone played the bass but in "I Believe In Miracles" & "Merry Christmas (I Don't Wanna Fight Tonight)", C. J. Ramone replaced Dee Dee's position as a bassist.