"Breathe" is the first single of Fabolous' album Real Talk. Having the feel of the New York's five boroughs at its core and named to exhale the old music, "Breathe" was eventually released as an official single and reached #10 on the Billboard Hot 100 in November 2004. The music has a big sound, especially due to the piano samples from Supertramp's "Crime of the Century". The single acquired remixes; one featuring 50 Cent and Mase; another with Noztra. The music video features cameos by The Game, Just Blaze, J. D. Williams, and DJ Clue.
Pitchfork Media named "Breathe" the number nine song of the year for 2004, stating "'Breathe' sounds like the track Fab was always meant to rap over."
The song was also listed by Pitchfork Media as the 288th best song of the 2000s. Complex named it number 60 on best songs of the decade.
The Beastie Boys performed their song "So What'cha Want" over the beat on Late Night with David Letterman in 2006.
Bay Area rappers Yukmouth and Gonzoe recorded a "Breathe" video using the instrumental track to diss Compton-based rapper The Game.