Brenda Chamberlain (1912–1971) was a Welsh artist and poet.
Born in Bangor, Wales, she studied art at the Royal Academy in London, but simultaneously developed an interest in poetry. Just before the Second World War, she moved in with artist John Petts, and together they set up the Caseg Press at their home. Chamberlain also produced prose works, including a novel and a memoir of life on Bardsey Island, where she lived from 1947. In 1961 she went to live on a Greek island, but later returned to Wales.