Nissen made an early appearance in Laurence Olivier's film of Shakespeare's Henry V, and made many TV, film, and stage appearances, including The Dam Busters (1955), and the television series The New Adventures of Charlie Chan and Sword of Freedom in 1957. But he is probably best-remembered as an in-vision announcer for Southern Television, where his formal style seemed to sum up the company's aesthetic. He joined Southern at its inception in 1958 and stayed until its demise in 1981, and was kept on by the successor company TVS despite its general policy of breaking with Southern's conservatism. He retired from TVS in August 1987. Nissen died on 8 February 2001 at the age of 73.