In 1969, Englishrock band Led Zeppelin recorded a version of the song for their album Led Zeppelin II. The intro and outro were deliberate homages to the Sonny Boy Williamson song, whereas the rest of the track was an original Jimmy Page/Robert Plant composition; however, Dixon was not given a lyric writing credit for the song. In 1972, Arc Music, the publishing arm of Chess Records, brought a lawsuit against Led Zeppelin for copyright infringement over "Bring It On Home"; the case was settled out of court for an undisclosed sum.
In an interview he gave in 1977, Page commented:
The thing with "Bring It On Home," there's only a tiny bit taken from Sonny Boy Williamson's version and we threw that in as a tribute to him. People say, "Oh, 'Bring It On Home' is stolen." Well, there's only a little bit in the song that relates to anything that had gone before it, just the end.
Plant's harmonica part was recorded in Vancouver. The band went on tour with the master tapes from Led Zeppelin II and now and then stopped into a studio to record parts.
Led Zeppelin frequently performed this song live at Led Zeppelin concerts, first appearing as an encore on the band's 1970 UK tour. When played live, the song exhibited sharp interplay between Jimmy Page's guitar, John Bonham's drums and John Paul Jones' bass. This can be seen on the Led Zeppelin DVD, which features a performance at the Royal Albert Hall in 1970. Another version dating from 1972 is included on the live release How the West Was Won which listed the song as a medley on the cover. "Bring It On Home" was credited to Dixon, while the middle section, newly named "Bring It On Back", was credited to Bonham/Jones/Page/Plant.