Bromethalin

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Bromethalin
Brometalin Formula V.2.svg
Identifiers
CAS number 63333-35-7 YesY
PubChem 44465
ChemSpider 40463 YesY
UNII GM59MTH1FS YesY
KEGG C18697 N
Jmol-3D images Image 1
Properties
Molecular formula C14H7Br3F3N3O4
Molar mass 577.93 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Bromethalin is a rodenticide which poisons the central nervous system by uncoupling mitochondrial oxidative phosphorylation, which causes a decrease in adenosine triphosphate (ATP) synthesis. Decreased ATP ultimately results in increased intracranial pressure, which damages neuronal axons. This damage to the central nervous system can cause paralysis, convulsions, and death.[1]

Risk of poisoning[edit]

There are no tests that will diagnose bromethalin poisoning in pets, but signs to watch for include severe muscle tremors, hyperexcitability, fits, extreme sensitivity to being touched (hyperesthesia) and seizures that appear to be caused by light or noise. Signs can be delayed for several days.

There is no antidote for bromethalin:care is symptomatic and supportive. Animals who have eaten it accidentally should seek immediate veterinary attention and be decontaminated. Contacting an animal poison control center can help that timely and appropriate therapy is started.

The mechanism of bromethalin toxicity differs from that of popular rodent poisons, which are anticoagulants related to warfarin (Coumadin). These drugs, such as diphacinone and bromadiolone, eaten by the mouse as an overdose, inhibit vitamin K and lead to a loss of clotting activity over several days (clotting factors require vitamin K). The ultimate result is hemorrhage.

While Bromethalin is labeled as a rodenticide, it is often used for rodent-like mammals such as moles and voles. It is often hidden inside a worm-like bait to attract moles.

References[edit]

  1. ^ Bromethalin, Animal Disease Diagnostic Laboratory, Spring 1997 Newsletter