He has a son, Faheem, from his first marriage, and remarried in 2008. The song "Real as Can Be" off his EPThe Truth Is Here says he also has a daughter on the way. In the song "Fresh Air" on his September 2009 album Us, he goes on to say "Just got married last year/ treated so good that it ain't even fair/ already got a boy now the baby girl's here/ Bought us a house like the Berenstein Bears." He also is the Godfather to Mackenzie, Brien, and Calvin Pine.
Ali was born with the rare genetic condition of albinism, a disorder characterized by a lack of pigment in skin, eyes, and hair. Brother Ali often makes fun of the media's constant urge to mention his condition in the first lines of their reviews or newspaper articles. He is also legally blind which is caused by his albinism.
While Brother Ali's family is white, he has often described a childhood marked by cruelty and exclusion by his white classmates as a result of his physical abnormality. He has often explained that, from an early age, he felt "most at home amongst African Americans."
Brother Ali has said many times in interviews that he finds much of his inspiration in the late 1980s rappers of the golden age of hip hop, especially KRS-One and Rakim. In the track "Get Up Stand Up" by Public Enemy, in which Brother Ali features, he says 'I was raised by the Enemy, and ever since then that's been my identity', suggesting that he also sees Public Enemy as an inspiration. 
Brother Ali has been under pressure from the recording industry due to lyrics from his song "Uncle Sam Goddamn", claiming creative interference from "somebody I don't wanna name, but some of you probably has their cell phones." The unnamed corporation ultimately withdrew its sponsorship of Ali, causing him to truncate parts of his 2007 tour. Furthermore, on the song "Second Time Around" with Benzi and Wale, Ali makes references to being kicked off a tour followed by the line "Verizon dissed me too, cuz I was too political." The song is notably critical of the United States government, with accusations that the political system is addicted to war.