Brown tumor

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Brown tumor
Classification and external resources
Brown tumours of the hands.jpg
Brown tumours of the hands in a patient with hyperparathyroidism.
ICD-9 252.01
DiseasesDB 30721
MeSH D010002

The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. It is not a true neoplasm, as the term "tumor" suggests; however, it may mimic a true neoplasm.[1] Brown tumours are radiolucent on x-ray.

Pathology[edit]

Micrograph of a brown tumor (left of image). H&E stain.

Brown tumours consist of fibrous tissue, woven bone and supporting vasculature, but no matrix. The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone deposition followed by additional resorption can expand beyond the usual shape of the bone, involving the periosteum thus causing bone pain. The characteristic brown coloration results from hemosiderin deposition into the osteolytic cysts. Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen giant cell tumors of the bone.[2][3]

Brown tumors may be rarely associated with ectopic parathyroid adenomas.[4]

See also[edit]

References[edit]

  1. ^ Meydan N, Barutca S, Guney E, et al. (June 2006). "Brown tumors mimicking bone metastases". J Natl Med Assoc 98 (6): 950–3. PMC 2569361. PMID 16775919. 
  2. ^ Aoki, J.; Moriya, K.; Yamashita, K.; Fujioka, F.; Ishii, K.; Karakida, O.; Imai, S.; Sakai, F. et al. (1991). "Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation". J Comput Assist Tomogr 15 (6): 1024–7. doi:10.1097/00004728-199111000-00023. PMID 1939753. 
  3. ^ Matsushige, T.; Nakaoka, M.; Yahara, K.; Kagawa, K.; Miura, H.; Ohnuma, H.; Kurisu, K. (Aug 2008). "Giant cell tumor of the temporal bone with intratumoral hemorrhage". J Clin Neurosci 15 (8): 923–7. doi:10.1016/j.jocn.2007.03.013. PMID 18554912. 
  4. ^ Sharma, Ravi; Mathan Mohan; R S Neelakandan; D Siddharth (October 2013). "An unusual case of brown tumor of hyperparathyroidism associated with ectopic parathyroid adenoma". European Journal of Dentistry 7 (4): 500–503. doi:10.4103/1305-7456.120657. Retrieved 2013-10-28.