Brunner syndrome
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| Brunner syndrome | |
|---|---|
| Classification and external resources | |
| OMIM | 300615 |
| DiseasesDB | 32391 |
Brunner syndrome is a rare genetic disorder caused by a mutation in the MAOA gene. It is characterized by mild mental retardation and problematic impulsive behavior (such as arson, hypersexuality, and aggressive posturing).[1] It is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and epinephrine.
It was characterized in 1993.[2]
[edit] References
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 300615
- ^ Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA (October 1993). "Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A". Science 262 (5133): 578–80. doi:10.1126/science.8211186. PMID 8211186. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8211186.
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