Buccal administration refers to the pharmacologicalroute of administration by which drugs diffuse into the blood through tissues of the buccal vestibule, the area inside the mouth between the lining of cheek (the buccal mucosa) and the teeth / gums. Certain medications are designed to be given bucally (as opposed to orally or sublingually). Buccal (as opposed to oral) administration usually results in a more rapid onset of action, since the medication need not pass through the digestive system and can be absorbed directly through the skin. There is current research on developing buccal morphine and fentanyl, as well as insulin. Some sedatives can be given buccally, e.g. midazolam.