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Buccal administration refers to a topical route of administration by which drugs diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream. Buccal administration typically results in higher bioavailability of a drug a more rapid onset of action. This is because the medication does not pass through the digestive system and thereby avoids first pass metabolism. There is current research on developing buccal morphine and fentanyl, as well as insulin. Some sedatives can be given buccally, e.g. midazolam.