Bucolome

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Bucolome
Bucolome.png
Systematic (IUPAC) name
5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 841-73-6
ATC code None
PubChem CID 2461
ChemSpider 2367 YesY
UNII 9T08RAL174 YesY
ChEBI CHEBI:31314 YesY
ChEMBL CHEMBL2106136
Synonyms Bucolome, Paramidine
Chemical data
Formula C14H22N2O3 
Mol. mass 224.256 g/mol
 YesY (what is this?)  (verify)

Bucolome (Paramidine) is a barbiturate derivative. Unlike most barbiturates it does not have any significant sedative or hypnotic effects, but instead acts as an analgesic and antiinflammatory. It also acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites.[1][2][3]

References[edit]

  1. ^ Takamura N, Maruyama T, Chosa E, Kawai K, Tsutsumi Y, Uryu Y, Yamasaki K, Deguchi T, Otagiri M. Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome. Drug Metabolism and Disposition. 2005 Apr;33(4):596-602. PMID 15640375
  2. ^ Osawa M, Hada N, Matsumoto K, Hasegawa T, Kobayashi D, Morimoto Y, Yamaguchi M, Kanamoto I, Nakagawa T, Sugibayashi K. Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions. International Journal of Pharmaceutics. 2005 Apr 11;293(1-2):43-9. PMID 15778043
  3. ^ Kobayashi M, Takagi M, Fukumoto K, Kato R, Tanaka K, Ueno K. The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan. Drug Metabolism and Pharmacokinetics. 2008;23(2):115-9. PMID 18445991