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Bufotoxins are a family of toxic steroid lactones found in the parotoid glands, skin and venom of many toads (genus Bufo); other amphibians; and some plants and mushrooms.[1] The exact composition varies greatly with the specific source of the toxin. It can contain: 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, epinephrine, norepinephrine, and serotonin. The term bufotoxin can also be used specifically to describe the conjugate of a bufagin with suberylargine.[2]

The toxic substances found in toads can be divided by chemical structure in two groups:

Toads known to secrete bufotoxin are:[citation needed]


Extract from the skin of certain Asian toads, such as Bufo bufo gargarizans, is often found in certain Chinese folk remedies.


  1. ^ Siperstein et al., 1957; Lincoff & Mitchel, 1977; Kibmer & Wichtl, 1986
  2. ^ Chen & Kovarikova, 1967

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