Busoga sub-region is a region in Eastern Uganda that consists of the following districts:
- Bugiri District
- Buyende District
- Iganga District
- Jinja District
- Kaliro District
- Kamuli District
- Luuka District
- Mayuge District
- Namayingo District
- Namutumba District
The area covered by the above districts constitutes the traditional Busoga Kingdom. Milton Obote abolished the traditional kingdoms in Uganda in 1967. When Yoweri Museveni re-established them in 1993, Busoga re-constituted itself.
The sub-region is home mainly to the Basoga ethnic group. The people of Busoga are called Basoga (singular: Musoga). The Basoga speak Lusoga, a Bantu language. Lusoga is similar to Luganda, spoken by the people of the neighboring Buganda Region, which is also referred to as Central Uganda.
According to the 2002 national census, the Busoga sub-region was home to an estimated 2.5 million people at that time.
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