Buthionine sulfoximine

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Buthionine sulfoximine
Skeletal formula of buthionine sulfoximine
Ball-and-stick model of buthionine sulfoximine as a zwitterion
Names
IUPAC name
2-amino-4-(butylsulfonimidoyl)butanoic acid
Identifiers
5072-26-4 N
ChEBI CHEBI:28714 YesY
ChemSpider 19896 YesY
Jmol-3D images Image
MeSH Buthionine+sulfoximine
PubChem 21157
Properties
C8H18N2O3S
Molar mass 222.305 g/mol
Density 1.29 g/mL
Melting point 215 °C (419 °F; 488 K)
Boiling point 382.3 °C (720.1 °F; 655.5 K)
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Buthionine sulfoximine is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer.[1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.[2]

References[edit]

  1. ^ Defty, CL; Marsden, JR (2012). "Melphalan in regional chemotherapy for locally recurrent metastatic melanoma.". Current topics in medicinal chemistry 12 (1): 53–60. PMID 22196271. 
  2. ^ "Definition of buthionine sulfoximine - National Cancer Institute Drug Dictionary".