Butyrate kinase

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butyrate kinase
Identifiers
EC number 2.7.2.7
CAS number 37278-14-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a butyrate kinase (EC 2.7.2.7) is an enzyme that catalyzes the chemical reaction

ATP + butanoate \rightleftharpoons ADP + butanoyl phosphate

Thus, the two substrates of this enzyme are ATP and butyrate, whereas its two products are ADP and butanoyl phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:butanoate 1-phosphotransferase. This enzyme participates in butyrate metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1SAZ and 1X9J.

References[edit]

  • Hartmanis MG (1987). "Butyrate kinase from Clostridium acetobutylicum". J. Biol. Chem. 262 (2): 617–21. PMID 3027059. 
  • Twarog R and Wolfe RS (1962). "Enzymatic phosphorylation of butyrate". J. Biol. Chem. 237: 2474–2477. PMID 13923331.