Butyryl-CoA dehydrogenase

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butyryl-CoA dehydrogenase
Identifiers
EC number 1.3.99.2
CAS number 9027-88-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a butyryl-CoA dehydrogenase (EC 1.3.99.2) is an enzyme that catalyzes the chemical reaction

butyryl-CoA + acceptor \rightleftharpoons 2-butenoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are butyryl-CoA and an acceptor, whereas its two products are 2-butenoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is butanoyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, and butanoyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, valine, leucine and isoleucine degradation, and butanoate metabolism. It employs one cofactor, FAD.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BUC and 1JQI.

References[edit]

  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466.
  • MAHLER HR, MACKLER B, GREEN DE (1954). "Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein". J. Biol. Chem. 210 (1): 465–80. PMID 13201608. 
  • HAUGE JG, CRANE FL, BEINERT H (1956). "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl coA dehydrogenase". J. Biol. Chem. 219 (2): 727–33. PMID 13319294. 
  • MAHLER HR (1954). "Studies on the fatty acid oxidizing system of animal tissues. IV The prosthetic group of butyryl coenzyme A dehydrogenase". J. Biol. Chem. 206 (1): 13–26. PMID 13130522.