The Andrews moved to Wisconsin for the purpose of Byron and four siblings to attend the Evansville Seminary of Wisconsin that was established by the local Methodist church to educate students for entrance into college. After graduation in 1871, he moved to Geneva, New York where in 1875, earned a B.A. degree in journalism at Hobart College, now known as Hobart and William Smith Colleges. Late in 1900 he earn honorary degree of the said college. 
Byron Andrews went directly from college to newspaper work and served as a reporter on the Chicago Daily News. Then for four years, he was the Washington correspondent of the Chicago Inter Ocean and the St. Paul Pioneer Press. In 1880 he accompanied U.S. President, General Ulysses S. Grant, on a tour through the West Indies, Mexico and Cuba as his secretary and as correspondent, of the Chicago Inter Ocean and New York Tribune. As early as 1880, he was advertising representative for newspapers National Tribune, American Farmer and Boston Commonwealth in offices of the World Building (aka Pulitzer Building) in New York City. In 1884 Byron Andrews accepted the position of editor for the National Tribune of Washington, D.C. at a salary of $5000 a year and a percent of the profits. By 1897 became one of the three owners of the said newspaper/publishing company. He also filled many public positions of trust.
Byron Andrews was the eldest child of John Cain Andrews (born in Norwalk, Ohio) and Sarah Wright (born in Barlestone, England). His siblings include: Marilla Andrews (wife of Edward Lyon Buchwalter), Eleanora Andrews, Jerome Andrews and Cassian Andrews.
Byron Andrews grandparents were Thomas Browne Andrews of Baltimore, Maryland and Mary (Cain) Andrews, who immigrated from Ireland in 1805. Moses Andrews, born in Cecil County, Maryland, was his great, grandfather whose brother was the notable Rev. John Andrews (clergyman),D.D., all direct descendants of Anthony Andrews (High Sheriff of Rutland), England, father of Edward Andrews (High Sheriff of Rutland).
- Notes on the Russio-Turkish W21ar.
- Biography of John A. Logan; and One of the People.
- Life and Speeches of William McKinley; With a Brief Sketch of Garrett A. Hobart.:
- The Story of Cuba;
- President Monroe and His Doctrine;
- Various historical and controversial pamphlets.
- Papers of Ulysses S. Grant: October 1, 1878 – September 20, 1880. P. 311
- Origin and History of the Name of Andrews with Biographies Of All the Most Noted Persons of That Name and Account of the Origin of Surnames and Forenames Together with Over Five Hundred Christian Names of Men and Women and Their Significance. The Crescent Family Record. Chicago, ILL.:American Publishers' Association. 1901. pp.22–23.
- Papers of Ulysses S. Grant: October 1, 1878 – September 20, 1880. p. 370.
- Herringshaw's National Library of American Biography: Contains Thirty-five thousand Biographies of the Acknowledged Leaders of Life and thought of the United States. Thomas William Herringshaw. 1909. P.128.
- Fourth Estate: A Weekly Newspaper for Publishers, Advertisers, Advertising Agents and Allied Interests. Frank H. Lancaster. 1919. P. 62
- The Enterprise (newspaper), p.1,col. 5, Evansville, Wisconsin February 12, 1884.
- One of the People: Life and Speeches of William McKinley; With a Brief Sketch of Garrett A. Hobart. ⓟ Byron Andrews. Printed by F.T. Neely,Chicago in 1896.