C-C chemokine receptor type 7

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Chemokine (C-C motif) receptor 7
Identifiers
Symbols CCR7 ; BLR2; CD197; CDw197; CMKBR7; EBI1
External IDs OMIM600242 MGI103011 HomoloGene1387 IUPHAR: CCR7 ChEMBL: 4594 GeneCards: CCR7 Gene
RNA expression pattern
PBB GE CCR7 206337 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1236 12775
Ensembl ENSG00000126353 ENSMUSG00000037944
UniProt P32248 P47774
RefSeq (mRNA) NM_001838 NM_007719
RefSeq (protein) NP_001829 NP_031745
Location (UCSC) Chr 17:
38.71 – 38.72 Mb
Chr 11:
99.14 – 99.16 Mb
PubMed search [1] [2]

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.[1] Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21).[2]

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

Function[edit]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lymphoid organs, such as lymph nodes, as well as stimulate dendritic cell maturation.

Clinical significance[edit]

CCR7 is expressed by various cancer cells, such as nonsmall lung cancer, gastric cancer and oesophageal cancer.[3][4][5] Expression of CCR7 by cancer cells is linked with metastasis to lymph nodes.[6]

References[edit]

  1. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol 67 (4): 2209–20. PMC 240341. PMID 8383238. 
  2. ^ F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
  3. ^ Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)
  4. ^ Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)
  5. ^ Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)
  6. ^ Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA (June 2007). "Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling". Cancer Cell 11 (6): 526–38. doi:10.1016/j.ccr.2007.04.020. PMID 17560334. 

External links[edit]

  • "Chemokine Receptors: CCR7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.