C-fos-induced growth factor

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C-fos induced growth factor (vascular endothelial growth factor D)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FIGF ; VEGF-D; VEGFD
External IDs OMIM300091 MGI108037 HomoloGene3288 GeneCards: FIGF Gene
RNA expression pattern
PBB GE FIGF 206742 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2277 14205
Ensembl ENSG00000165197 ENSMUSG00000031380
UniProt O43915 P97946
RefSeq (mRNA) NM_004469 NM_010216
RefSeq (protein) NP_004460 NP_034346
Location (UCSC) Chr X:
15.36 – 15.4 Mb
Chr X:
164.37 – 164.4 Mb
PubMed search [1] [2]

C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.[1]

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.[1]

Tumor metastasis to lymph nodes:

Lymph node metastasis is very often associated with several types of human malignancies. Cancer cells’ journey to lymph node takes place largely through lymphatic tunnel located in and around of primary tumor. VEGF-D’s interactions with VEGFR-3 predominantly expressed in lymphatic vessels plays a key role in restructuring lymphatic channel and, hence, able to alter its functions related to fluid and cell transport along the conduits. VEGF-D has been established to be over-expressed in both tumor tissues and patients’ serum samples in several types of human cancer. In addition, VEGF-D expression has been implicated with increased incidence of regional lymph node metastasis. In experimental mice study, genetically modified tumor cell that was forced to produce VEGF-D protein have been established to boost up regional lymph nodes metastases.[2]

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