C11orf30
From Wikipedia, the free encyclopedia
| Chromosome 11 open reading frame 30 | |||||||||||
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 PDB rendering based on 1utu. |
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| Identifiers | |||||||||||
| Symbols | C11orf30; EMSY; FLJ90741 | ||||||||||
| External IDs | OMIM: 608574 MGI: 1924203 HomoloGene: 32465 GeneCards: C11orf30 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 56946 | 233545 | |||||||||
| Ensembl | ENSG00000158636 | ENSMUSG00000035401 | |||||||||
| UniProt | Q7Z589 | Q8BMB0 | |||||||||
| RefSeq (mRNA) | NM_020193 | NM_172280.2 | |||||||||
| RefSeq (protein) | NP_064578 | NP_758484.2 | |||||||||
| Location (UCSC) | Chr 11: 76.16 – 76.26 Mb |
Chr 7: 105.74 – 105.81 Mb |
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| PubMed search | [1] | [2] | |||||||||
Protein EMSY is a protein that in humans is encoded by the C11orf30 gene.[1]
[edit] Interactions
C11orf30 has been shown to interact with ZMYND11,[2] BRCA2[2] and CBX1.[2]
[edit] References
- ^ "Entrez Gene: C11orf30 chromosome 11 open reading frame 30". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56946.
- ^ a b c Hughes-Davies, Luke; Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet-Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony (Nov. 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell (United States) 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. ISSN 0092-8674. PMID 14651845.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hughes-Davies L, Huntsman D, Ruas M, et al. (2004). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bera TK, Das S, Maeda H, et al. (2004). "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 3059–64. doi:10.1073/pnas.0308746101. PMC 365744. PMID 14981236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=365744.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ekblad CM, Chavali GB, Basu BP, et al. (2005). "Binding of EMSY to HP1β: implications for recruitment of HP1β and BS69". EMBO Rep. 6 (7): 675–80. doi:10.1038/sj.embor.7400415. PMC 1369107. PMID 15947784. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1369107.
- Chavali GB, Ekblad CM, Basu BP, et al. (2005). "Crystal structure of the ENT domain of human EMSY". J. Mol. Biol. 350 (5): 964–73. doi:10.1016/j.jmb.2005.05.047. PMID 15978617.
- Benusiglio PR, Lesueur F, Luccarini C, et al. (2006). "Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs". BMC Cancer 5: 81. doi:10.1186/1471-2407-5-81. PMC 1185523. PMID 16029503. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1185523.
- Raouf A, Brown L, Vrcelj N, et al. (2005). "Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY". J. Natl. Cancer Inst. 97 (17): 1302–6. doi:10.1093/jnci/dji254. PMID 16145051.
- Brown LA, Irving J, Parker R, et al. (2006). "Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas". Gynecol. Oncol. 100 (2): 264–70. doi:10.1016/j.ygyno.2005.08.026. PMID 16236351.
- Huang Y, Myers MP, Xu RM (2006). "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding". Structure 14 (4): 703–12. doi:10.1016/j.str.2006.01.007. PMID 16615912.
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