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Complement component 1, s subcomponent
Protein C1S PDB 1elv.png
PDB rendering based on 1elv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol C1S
External IDs OMIM120580 MGI1355312 HomoloGene1314 ChEMBL: 3913 GeneCards: C1S Gene
EC number
RNA expression pattern
PBB GE C1S 208747 s at tn.png
More reference expression data
Species Human Mouse
Entrez 716 50908
Ensembl ENSG00000182326 ENSMUSG00000038521
UniProt P09871 Q8CG14
RefSeq (mRNA) NM_001734 NM_001097617
RefSeq (protein) NP_001725 NP_001091086
Location (UCSC) Chr 12:
7.1 – 7.18 Mb
Chr 6:
124.53 – 124.54 Mb
PubMed search [1] [2]

Complement C1s subcomponent is a protein that in humans is encoded by the C1S gene.[1]


C1S has been shown to interact with C1R.[2][3]


  1. ^ "Entrez Gene: C1S Complement component 1, s subcomponent". 
  2. ^ Thielens, N M; Enrie K; Lacroix M; Jaquinod M; Hernandez J F; Esser A F; Arlaud G J (April 1999). "The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s". J. Biol. Chem. (UNITED STATES) 274 (14): 9149–59. doi:10.1074/jbc.274.14.9149. ISSN 0021-9258. PMID 10092586. 
  3. ^ Thiel, S; Petersen S V; Vorup-Jensen T; Matsushita M; Fujita T; Stover C M; Schwaeble W J; Jensenius J C (July 2000). "Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19". J. Immunol. (UNITED STATES) 165 (2): 878–87. doi:10.4049/jimmunol.165.2.878. ISSN 0022-1767. PMID 10878362. 

Further reading[edit]