C1q domain

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C1q domain
PDB 1o91 EBI.jpg
crystal structure of a collagen viii nc1 domain trimer
Symbol C1q
Pfam PF00386
Pfam clan CL0100
InterPro IPR001073
SCOP 1c28

In molecular biology, the C1q domain is a conserved protein domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system. C1q comprises 6 A, 6 B and 6 C chains. These share the same topology, each possessing a small, globular N-terminal domain, a collagen-like Gly/Pro-rich central region, and a conserved C-terminal region, the C1q domain.[1] The C1q protein is produced in collagen-producing cells and shows sequence and structural similarity to collagens VIII and X.[2][3]


  1. ^ Sellar GC, Blake DJ, Reid KB (March 1991). "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q". Biochem. J. 274 (2): 481–90. PMC 1150164. PMID 1706597. 
  2. ^ Petry F, Reid KB, Loos M (November 1989). "Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine Clq". FEBS Lett. 258 (1): 89–93. doi:10.1016/0014-5793(89)81622-9. PMID 2591537. 
  3. ^ Muragaki Y, Jacenko O, Apte S, Mattei MG, Ninomiya Y, Olsen BR (April 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1". J. Biol. Chem. 266 (12): 7721–7. PMID 2019595. 

This article incorporates text from the public domain Pfam and InterPro IPR001073