C2C12 is a mouse myoblast cell line. C2C12 cells were originally obtained by Yaffe and Saxel through serial passage of myoblasts cultured from the thigh muscle of C3H mice after a crush injury. These cells are capable of differentiation. C2C12 cells are a useful tool to study the differentiation of myoblast and osteoblast, to express various proteins, and to explore mechanistic pathways.
- David Yaffe and Ora Saxel (1977). "Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle.". Nature 270 (5639): 725–727. doi:10.1038/270725a0. PMID 563524.
|This biology article is a stub. You can help Wikipedia by expanding it.|