The classical and alternative complement pathways.
C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.
C3a plays an important role in
chemotaxis, though not as important a role as C5a. [1 ]
It is also an
anaphylatoxin and the precursor of the important cytokine ( adipokine) ASP through its interaction with carboxypeptidase B. [2 ]
References [ edit ]
^ Andreas Klos, Elisabeth Wende, Kathryn J. Wareham, and Peter N. Monk (2013). "International Union of Pharmacology. LXXXVII. Complement Peptide C5a, C4a, and C3a Receptors". Pharmacological Reviews 65 (1): 500–543. doi: 10.1124/pr.111.005223. PMID 23383423.
^ Onat A, Can G, Rezvani R, Cianflone K (June 2011). "Complement C3 and cleavage products in cardiometabolic risk". Clinica Chimica Acta (Amsterdam: Elsevier) 412 (13-14): 1171–9. doi: 10.1016/j.cca.2011.03.005. PMID 21419112.
Dinasarapu, A R; Chandrasekhar, A; Sahu, A; Subramaniam, S (2012). "Complement C3 (Human)". UCSD Molecule Pages. doi: 10.6072/H0.MP.A004235.01.
External links [ edit ]