C3a (complement)

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The classical and alternative complement pathways.

C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.

C3a plays an important role in chemotaxis, though not as important a role as C5a.[1]

It is also an anaphylatoxin and the precursor of the important cytokine (adipokine) ASP through its interaction with carboxypeptidase B.[2]


  1. ^ Andreas Klos, Elisabeth Wende, Kathryn J. Wareham, and Peter N. Monk (2013). "International Union of Pharmacology. LXXXVII. Complement Peptide C5a, C4a, and C3a Receptors". Pharmacological Reviews 65 (1): 500–543. doi:10.1124/pr.111.005223. PMID 23383423. 
  2. ^ Onat A, Can G, Rezvani R, Cianflone K (June 2011). "Complement C3 and cleavage products in cardiometabolic risk". Clinica Chimica Acta (Amsterdam: Elsevier) 412 (13-14): 1171–9. doi:10.1016/j.cca.2011.03.005. PMID 21419112. 
  • Dinasarapu, A R; Chandrasekhar, A; Sahu, A; Subramaniam, S (2012). "Complement C3 (Human)". UCSD Molecule Pages. doi:10.6072/H0.MP.A004235.01. 

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