C3a receptor

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Complement component 3a receptor 1
Symbols C3AR1 ; AZ3B; C3AR; HNFAG09
External IDs OMIM605246 MGI1097680 HomoloGene2992 IUPHAR: 31 ChEMBL: 4761 GeneCards: C3AR1 Gene
RNA expression pattern
PBB GE C3AR1 209906 at tn.png
More reference expression data
Species Human Mouse
Entrez 719 12267
Ensembl ENSG00000171860 ENSMUSG00000040552
UniProt Q16581 O09047
RefSeq (mRNA) NM_004054 NM_009779
RefSeq (protein) NP_004045 NP_033909
Location (UCSC) Chr 12:
8.21 – 8.22 Mb
Chr 6:
122.85 – 122.86 Mb
PubMed search [1] [2]

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.[1][2]

Although its official name implies it only binds C3a, it also binds C4a.[3]


  1. ^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247. 
  2. ^ Ali H, Panettieri RA (2005). "Anaphylatoxin C3a receptors in asthma". Respir. Res. 6: 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703. 
  3. ^ Klos A, Wende E, Wareham KJ, Monk PN. (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423. 

Further reading[edit]

External links[edit]