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C4ISR may refer to:
- the C4ISR concept of Command, Control, Communications, Computers, Intelligence, Surveillance and Reconnaissance, the U.S. term for C4ISTAR
- C4ISR Journal, a journal published by the Defense News Media Group
- the C4ISR architectural framework (C4ISR AF), now known as Department of Defense Architecture Framework (DoDAF)
- Command and control
- STA sniper (USMC)
- Surveillance and Target Acquisition
- Artillery STA
- Military intelligence
- Information Warfare
- Programs include Command Post of the Future (CPOF), C2PC, FBCB2, and MCS
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