C8 complex

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High Resolution Crystal Structure of Human Complement Component 8
complement component 8, alpha polypeptide
Identifiers
Symbol C8A
Entrez 731
HUGO 1352
OMIM 120950
RefSeq NM_000562
UniProt P07357
Other data
Locus Chr. 1 p36.2-22.1
complement component 8, beta polypeptide
Identifiers
Symbol C8B
Entrez 732
HUGO 1353
OMIM 1209660
RefSeq NM_000066
UniProt P073o58
Other data
Locus Chr. 1 p36.2-22.1
complement component 8, gamma polypeptide
Identifiers
Symbol C8G
Entrez 733
HUGO 1354
OMIM 120930
RefSeq NM_000606
UniProt P07360
Other data
Locus Chr. 9 q34.3

Complement component 8 is a protein involved in the complement system. A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.

References[edit]

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

External links[edit]

The crystal structure is now in the PDB, PDB ID 3OJY.