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Carbonic anhydrase XIV
Crystal structure of the human carbonic anhydrase XIV with acetazolamide (spheres) bound. PDB entry 4lu3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CA14 ; CAXiV
External IDs OMIM604832 MGI1344341 HomoloGene69105 IUPHAR: 2598 ChEMBL: 3510 GeneCards: CA14 Gene
EC number
RNA expression pattern
PBB GE CA14 219464 at tn.png
More reference expression data
Species Human Mouse
Entrez 23632 23831
Ensembl ENSG00000118298 ENSMUSG00000038526
UniProt Q9ULX7 Q9WVT6
RefSeq (mRNA) NM_012113 NM_011797
RefSeq (protein) NP_036245 NP_035927
Location (UCSC) Chr 1:
150.23 – 150.24 Mb
Chr 3:
95.9 – 95.9 Mb
PubMed search [1] [2]

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.[1][2]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.[2]

In melanocytic cells CA14 gene expression may be regulated by MITF.[3]


  1. ^ Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Nov 1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1". Genomics 61 (1): 74–81. doi:10.1006/geno.1999.5938. PMID 10512682. 
  2. ^ a b "Entrez Gene: CA14 carbonic anhydrase XIV". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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