CA5B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Carbonic anhydrase VB, mitochondrial
Identifiers
Symbols CA5B ; CA-VB
External IDs OMIM300230 MGI1926249 HomoloGene21413 ChEMBL: 3969 GeneCards: CA5B Gene
EC number 4.2.1.1
RNA expression pattern
PBB GE CA5B 207129 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11238 56078
Ensembl ENSG00000169239 ENSMUSG00000031373
UniProt Q9Y2D0 Q9QZA0
RefSeq (mRNA) NM_007220 NM_181315
RefSeq (protein) NP_009151 NP_851832
Location (UCSC) Chr X:
15.71 – 15.81 Mb
Chr X:
163.98 – 164.03 Mb
PubMed search [1] [2]

Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene.[1][2]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.[2]

References[edit]

  1. ^ Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Aug 1999). "Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x". J Biol Chem 274 (30): 21228–33. doi:10.1074/jbc.274.30.21228. PMID 10409679. 
  2. ^ a b "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial". 

Further reading[edit]