CACNA1I

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Calcium channel, voltage-dependent, T type, alpha 1I subunit
Identifiers
Symbols CACNA1I ; Cav3.3; ca(v)3.3
External IDs OMIM608230 MGI2178051 HomoloGene69331 IUPHAR: Cav3.3 ChEMBL: 5558 GeneCards: CACNA1I Gene
Orthologs
Species Human Mouse
Entrez 8911 239556
Ensembl ENSG00000100346 ENSMUSG00000022416
UniProt Q9P0X4 E0CXK2
RefSeq (mRNA) NM_001003406 NM_001044308
RefSeq (protein) NP_001003406 NP_001037773
Location (UCSC) Chr 22:
39.97 – 40.09 Mb
Chr 15:
80.29 – 80.4 Mb
PubMed search [1] [2]

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.[1][2][3]

Function[edit]

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[1]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit". 
  2. ^ Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. 
  3. ^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.