CACNA2D1

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Calcium channel, voltage-dependent, alpha 2/delta subunit 1
Identifiers
Symbols CACNA2D1 ; CACNA2; CACNL2A; CCHL2A
External IDs OMIM114204 MGI88295 HomoloGene579 ChEMBL: 1919 GeneCards: CACNA2D1 Gene
RNA expression pattern
PBB GE CACNA2D1 207050 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 781 12293
Ensembl ENSG00000153956 ENSMUSG00000040118
UniProt P54289 O08532
RefSeq (mRNA) NM_000722 NM_001110843
RefSeq (protein) NP_000713 NP_001104313
Location (UCSC) Chr 7:
81.58 – 82.07 Mb
Chr 5:
15.93 – 16.37 Mb
PubMed search [1] [2]

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.[1][2]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

See also[edit]

Target for Gabapentinoids[edit]

alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.[3]

References[edit]

  1. ^ Powers PA, Scherer SW, Tsui LC, Gregg RG, Hogan K (Jun 1994). "Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis". Genomics 19 (1): 192–3. doi:10.1006/geno.1994.1044. PMID 8188232. 
  2. ^ a b "Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1". 
  3. ^ Rogawski MA, Bazil CW (July 2008). "New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–52. PMID 18590620. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.