CACNA2D2

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Calcium channel, voltage-dependent, alpha 2/delta subunit 2
Identifiers
Symbols CACNA2D2 ; CACNA2D
External IDs OMIM607082 MGI1929813 HomoloGene4400 ChEMBL: 3896 GeneCards: CACNA2D2 Gene
RNA expression pattern
PBB GE CACNA2D2 204811 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9254 56808
Ensembl ENSG00000007402 ENSMUSG00000010066
UniProt Q9NY47 Q6PHS9
RefSeq (mRNA) NM_001005505 NM_001174047
RefSeq (protein) NP_001005505 NP_001167518
Location (UCSC) Chr 3:
50.4 – 50.54 Mb
Chr 9:
107.4 – 107.53 Mb
PubMed search [1] [2]

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[1]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.