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Calcium channel, voltage-dependent, gamma subunit 1
External IDs OMIM114209 MGI1206582 HomoloGene582 GeneCards: CACNG1 Gene
RNA expression pattern
PBB GE CACNG1 206612 at tn.png
More reference expression data
Species Human Mouse
Entrez 786 12299
Ensembl ENSG00000108878 ENSMUSG00000020722
UniProt Q06432 O70578
RefSeq (mRNA) NM_000727 NM_007582
RefSeq (protein) NP_000718 NP_031608
Location (UCSC) Chr 17:
65.04 – 65.05 Mb
Chr 11:
107.7 – 107.72 Mb
PubMed search [1] [2]

Voltage-dependent calcium channel gamma-1 subunit is a protein that in humans is encoded by the CACNG1 gene.[1][2]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.[2]

See also[edit]


  1. ^ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940. 
  2. ^ a b "Entrez Gene: CACNG1 calcium channel, voltage-dependent, gamma subunit 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.