CACNG2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Calcium channel, voltage-dependent, gamma subunit 2
Identifiers
Symbols CACNG2 ; MRD10
External IDs OMIM602911 MGI1316660 HomoloGene4432 GeneCards: CACNG2 Gene
RNA expression pattern
PBB GE CACNG2 214495 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10369 12300
Ensembl ENSG00000166862 ENSMUSG00000019146
UniProt Q9Y698 O88602
RefSeq (mRNA) NM_006078 NM_007583
RefSeq (protein) NP_006069 NP_031609
Location (UCSC) Chr 22:
36.56 – 36.7 Mb
Chr 15:
77.99 – 78.12 Mb
PubMed search [1] [2]

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.[1]

Function[edit]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which having been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.[1]

Stargazin is involved in the transportation of AMPA receptors to the synaptic membrane, and the regulation of their receptor rate constants — via its extracellular domain — once it is there. As it is highly expressed throughout the cerebral cortex, it is likely to have an important role in learning within these areas, due to the importance of AMPA receptors in LTP.

Interactions[edit]

CACNG2 has been shown to interact with GRIA4[2] and DLG4.,[2][3] MAGI2 [4]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CACNG2 calcium channel, voltage-dependent, gamma subunit 2". 
  2. ^ a b Chen, L; Chetkovich D M; Petralia R S; Sweeney N T; Kawasaki Y; Wenthold R J; Bredt D S; Nicoll R A (2000). "Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms". Nature (England) 408 (6815): 936–43. doi:10.1038/35050030. ISSN 0028-0836. PMID 11140673. 
  3. ^ Choi, Jeonghoon; Ko Jaewon; Park Eunhye; Lee Jae-Ran; Yoon Jiyoung; Lim Sangmi; Kim Eunjoon (Apr 2002). "Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95". J. Biol. Chem. (United States) 277 (14): 12359–63. doi:10.1074/jbc.M200528200. ISSN 0021-9258. PMID 11805122. 
  4. ^ Deng, F. and Price, M.G. and Davis, C.F. and Mori, M. and Burgess, D.L (2006). "Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain". Journal of Neuroscience 26 (30): 7875–84. doi:10.1523/JNEUROSCI.1851-06.2006. PMID 16870733. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.