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Ca++-dependent secretion activator
Protein CADPS PDB 1wi1.png
PDB rendering based on 1wi1.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM604667 MGI1350922 HomoloGene2755 GeneCards: CADPS Gene
Species Human Mouse
Entrez 8618 27062
Ensembl ENSG00000163618 ENSMUSG00000054423
UniProt Q9ULU8 Q80TJ1
RefSeq (mRNA) NM_003716 NM_001042617
RefSeq (protein) NP_003707 NP_001036082
Location (UCSC) Chr 3:
62.38 – 62.86 Mb
Chr 14:
12.37 – 12.82 Mb
PubMed search [1] [2]

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.[1][2]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.[2]


  1. ^ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133. 
  2. ^ a b "Entrez Gene: CADPS Ca2+-dependent secretion activator". 

Further reading[edit]