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Ca++-dependent secretion activator 2
Symbols CADPS2 ; FLJ40851; KIAA1591
External IDs OMIM609978 MGI2443963 HomoloGene23060 GeneCards: CADPS2 Gene
RNA expression pattern
PBB GE CADPS2 219572 at tn.png
More reference expression data
Species Human Mouse
Entrez 93664 320405
Ensembl ENSG00000081803 ENSMUSG00000017978
UniProt Q86UW7 Q8BYR5
RefSeq (mRNA) NM_001009571 NM_001252105
RefSeq (protein) NP_001009571 NP_001239034
Location (UCSC) Chr 7:
121.96 – 122.53 Mb
Chr 6:
23.26 – 23.84 Mb
PubMed search [1] [2]

Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.[1]


This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells.[1]


This gene interacts with brain-derived neurotrophic factor.

Clinical significance[edit]

Cadps2 has been linked to autism[2] and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.[3]

A knockout mouse model was found to have autistic-like characteristics.[2]

CADPS2 has been linked to human and mouse brain structure in two large genomic studies.[4][5]


  1. ^ a b "Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2". National Center for Biotechnology Information. 
  2. ^ a b Sadakata, T; Washida, M; Iwayama, Y et al. (2007). "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". Journal of Clinical Investigation 117 (4): 931–43. doi:10.1172/JCI29031. PMC 1821065. PMID 17380209. 
  3. ^ Eran, Alal; Graham, Kaitlin R.; Vatalaro, Kayla et al. (April 2009). "Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients"". Journal of Clinical Investigation 119 (4): 679–80. doi:10.1172/JCI38620. PMID 19339759. 
  4. ^ French, L.; Pavlidis, P. (6 January 2011). "Relationships between gene expression and brain wiring in the adult rodent brain". PLoS Computational Biology 7 (1): e1001049. doi:10.1371/journal.pcbi.1001049. PMC 3017102. PMID 21253556. 
  5. ^ Stein, JL; Hua, X; Lee, S et al. (15 November 2010). "Voxelwise genome-wide association study (vGWAS)". Neuroimage 53 (3): 1160–74. doi:10.1016/j.neuroimage.2010.02.032. PMID 20171287. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.