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Calmodulin 2 (phosphorylase kinase, delta)
Protein CALM2 PDB 1a29.png
PDB rendering based on 1a29.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM114182 MGI103250 HomoloGene134804 GeneCards: CALM2 Gene
EC number
Species Human Mouse
Entrez 805 640703
Ensembl ENSG00000143933 ENSMUSG00000036438
UniProt P62158 P62204
RefSeq (mRNA) NM_001743 NM_007589
RefSeq (protein) NP_001734 NP_031615
Location (UCSC) Chr 14:
90.4 – 90.41 Mb
Chr 17:
87.83 – 87.85 Mb
PubMed search [1] [2]

Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.[1][2]

Clinical significance[edit]

Mutations in CALM2 are associated to cardiac arrhythmias .[3]


CALM2 has been shown to interact with AKAP9.[4][5]

See also[edit]


  1. ^ "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)". 
  2. ^ SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". J. Biol. Chem. 262 (34): 16663–70. PMID 2445749. 
  3. ^ Makita, N; Yagihara, N; Crotti, L; Johnson, C. N.; Beckmann, B. M.; Roh, M. S.; Shigemizu, D; Lichtner, P; Ishikawa, T; Aiba, T; Homfray, T; Behr, E. R.; Klug, D; Denjoy, I; Mastantuono, E; Theisen, D; Tsunoda, T; Satake, W; Toda, T; Nakagawa, H; Tsuji, Y; Tsuchiya, T; Yamamoto, H; Miyamoto, Y; Endo, N; Kimura, A; Ozaki, K; Motomura, H; Suda, K et al. (2014). "Novel Calmodulin (CALM2) Mutations Associated with Congenital Arrhythmia Susceptibility". Circulation: Cardiovascular Genetics. doi:10.1161/CIRCGENETICS.113.000459. PMID 24917665.  edit
  4. ^ Takahashi, Mikiko; Yamagiwa Akiko; Nishimura Tamako; Mukai Hideyuki; Ono Yoshitaka (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell (United States) 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. ISSN 1059-1524. PMC 124155. PMID 12221128. 
  5. ^ Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE (May 1993). "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3". Genomics 16 (2): 461–5. doi:10.1006/geno.1993.1211. PMID 8314583. 

Further reading[edit]