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Calmodulin-like 5
Protein CALML5 PDB 2b1u.png
PDB rendering based on 2b1u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CALML5 ; CLSP
External IDs OMIM605183 MGI1931464 HomoloGene49485 GeneCards: CALML5 Gene
RNA expression pattern
PBB GE CALML5 220414 at tn.png
More reference expression data
Species Human Mouse
Entrez 51806 80796
Ensembl ENSG00000178372 ENSMUSG00000033765
UniProt Q9NZT1 Q9JM83
RefSeq (mRNA) NM_017422 NM_020036
RefSeq (protein) NP_059118 NP_064420
Location (UCSC) Chr 10:
5.54 – 5.54 Mb
Chr 13:
3.84 – 3.84 Mb
PubMed search [1] [2]

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.[1][2]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.[2]


  1. ^ Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582. 
  2. ^ a b "Entrez Gene: CALML5 calmodulin-like 5". 

Further reading[edit]