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Calcium/calmodulin-dependent protein kinase II alpha
Protein CAMK2A PDB 1hkx.png
PDB rendering based on 1hkx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CAMK2A ; CAMKA
External IDs OMIM114078 MGI88256 HomoloGene56577 ChEMBL: 4147 GeneCards: CAMK2A Gene
EC number
Species Human Mouse
Entrez 815 12322
Ensembl ENSG00000070808 ENSMUSG00000024617
UniProt Q9UQM7 P11798
RefSeq (mRNA) NM_015981 NM_001286809
RefSeq (protein) NP_057065 NP_001273738
Location (UCSC) Chr 5:
149.6 – 149.67 Mb
Chr 18:
60.93 – 60.99 Mb
PubMed search [1] [2]

Calcium/calmodulin-dependent protein kinase type II alpha chain is an enzyme that in humans is encoded by the CAMK2A gene.[1][2]

The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]


CAMK2A has been shown to interact with Actinin alpha 4,[4] DLG1[5] and CDK5R1.[6]


  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
  2. ^ Lin CR, Kapiloff MS, Durgerian S, Tatemoto K, Russo AF, Hanson P, Schulman H, Rosenfeld MG (Sep 1987). "Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase". Proc Natl Acad Sci U S A 84 (16): 5962–6. doi:10.1073/pnas.84.16.5962. PMC 298983. PMID 3475713. 
  3. ^ "Entrez Gene: CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha". 
  4. ^ Walikonis, R S; Oguni A; Khorosheva E M; Jeng C J; Asuncion F J; Kennedy M B (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. (United States) 21 (2): 423–33. PMID 11160423. 
  5. ^ Gardoni, Fabrizio; Mauceri Daniela; Fiorentini Chiara; Bellone Camilla; Missale Cristina; Cattabeni Flaminio; Di Luca Monica (Nov 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. (United States) 278 (45): 44745–52. doi:10.1074/jbc.M303576200. ISSN 0021-9258. PMID 12933808. 
  6. ^ Dhavan, Rani; Greer Paul L; Morabito Maria A; Orlando Lianna R; Tsai Li-Huei (Sep 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. (United States) 22 (18): 7879–91. PMID 12223541. 

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