CAPN10

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Calpain 10
Identifiers
Symbols CAPN10 ; CANP10; NIDDM1
External IDs OMIM605286 MGI1344392 HomoloGene36323 GeneCards: CAPN10 Gene
RNA expression pattern
PBB GE CAPN10 219333 s at tn.png
PBB GE CAPN10 221040 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11132 23830
Ensembl ENSG00000142330 ENSMUSG00000026270
UniProt Q9HC96 Q9ESK3
RefSeq (mRNA) NM_021251 NM_011796
RefSeq (protein) NP_075571 NP_035926
Location (UCSC) Chr 2:
241.53 – 241.56 Mb
Chr 1:
92.93 – 92.95 Mb
PubMed search [1] [2]

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.[1][2]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.[3]

References[edit]

  1. ^ Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI (Nov 2000). "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus". Nat Genet 26 (2): 163–75. doi:10.1038/79876. PMID 11017071. 
  2. ^ Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C (Oct 2000). "A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance". J Clin Invest 106 (7): R69–73. doi:10.1172/JCI10665. PMC 387246. PMID 11018080. 
  3. ^ "Entrez Gene: CAPN10 calpain 10". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C02.018