CAPN5

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Calpain 5
Identifiers
Symbols CAPN5 ; HTRA3; nCL-3
External IDs OMIM602537 MGI1100859 HomoloGene31212 GeneCards: CAPN5 Gene
RNA expression pattern
PBB GE CAPN5 205166 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 726 12337
Ensembl ENSG00000149260 ENSMUSG00000035547
UniProt O15484 O08688
RefSeq (mRNA) NM_004055 NM_007602
RefSeq (protein) NP_004046 NP_031628
Location (UCSC) Chr 11:
76.78 – 76.84 Mb
Chr 7:
98.12 – 98.18 Mb
PubMed search [1] [2]

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.[1][2][3]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[3]

References[edit]

  1. ^ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024. 
  2. ^ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857. 
  3. ^ a b "Entrez Gene: CAPN5 calpain 5". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C02.011