CAPNS1

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Calpain, small subunit 1

PDB rendering based on 1aj5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CAPNS1 ; 30K; CALPAIN4; CANP; CANPS; CAPN4; CDPS; CSS1
External IDs OMIM114170 MGI88266 HomoloGene1327 ChEMBL: 4962 GeneCards: CAPNS1 Gene
EC number 3.4.22.17
Orthologs
Species Human Mouse
Entrez 826 12336
Ensembl ENSG00000126247 ENSMUSG00000001794
UniProt P04632 O88456
RefSeq (mRNA) NM_001003962 NM_009795
RefSeq (protein) NP_001003962 NP_033925
Location (UCSC) Chr 19:
36.63 – 36.64 Mb
Chr 7:
30.19 – 30.2 Mb
PubMed search [1] [2]

Calpain small subunit 1 is a protein that in humans is encoded by the CAPNS1 gene.[1][2][3]

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.[3]

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