Caspase recruitment domain-containing protein 10 is an enzyme that in humans is encoded by the CARD10gene.
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NFKB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NFKB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]
^Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J Biol Chem276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID11259443.
^Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett496 (2-3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID11356195.
^Wang, L; Guo Y, Huang W J, Ke X, Poyet J L, Manji G A, Merriam S, Glucksmann M A, DiStefano P S, Alnemri E S, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. (United States) 276 (24): 21405–9. doi:10.1074/jbc.M102488200. ISSN0021-9258. PMID11259443.Cite uses deprecated parameters (help)
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature402 (6761): 489–95. doi:10.1038/990031. PMID10591208.
McAllister-Lucas LM, Inohara N, Lucas PC, et al. (2001). "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.". J. Biol. Chem.276 (33): 30589–97. doi:10.1074/jbc.M103824200. PMID11387339.
Stilo R, Liguoro D, Di Jeso B, et al. (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.". J. Biol. Chem.279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID15184390.