CARD10

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Caspase recruitment domain family, member 10
Identifiers
Symbols CARD10 ; BIMP1; CARMA3
External IDs OMIM607209 MGI2146012 HomoloGene8728 GeneCards: CARD10 Gene
RNA expression pattern
PBB GE CARD10 210025 s at tn.png
PBB GE CARD10 210026 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 29775 105844
Ensembl ENSG00000100065 ENSMUSG00000033170
UniProt Q9BWT7 P58660
RefSeq (mRNA) NM_014550 NM_130859
RefSeq (protein) NP_055365 NP_570929
Location (UCSC) Chr 22:
37.89 – 37.92 Mb
Chr 15:
78.78 – 78.8 Mb
PubMed search [1] [2]

Caspase recruitment domain-containing protein 10 is an enzyme that in humans is encoded by the CARD10 gene.[1][2][3]

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NFKB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NFKB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM][3]

Interactions[edit]

CARD10 has been shown to interact with BCL10.[4]

References[edit]

  1. ^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J Biol Chem 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443. 
  2. ^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett 496 (2-3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195. 
  3. ^ a b "Entrez Gene: CARD10 caspase recruitment domain family, member 10". 
  4. ^ Wang, L; Guo Y, Huang W J, Ke X, Poyet J L, Manji G A, Merriam S, Glucksmann M A, DiStefano P S, Alnemri E S, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. (United States) 276 (24): 21405–9. doi:10.1074/jbc.M102488200. ISSN 0021-9258. PMID 11259443. 

Further reading[edit]