CARD11

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Caspase recruitment domain family, member 11
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CARD11 ; BENTA; BIMP3; CARMA1; IMD11; PPBL
External IDs OMIM607210 MGI1916978 HomoloGene13024 GeneCards: CARD11 Gene
Orthologs
Species Human Mouse
Entrez 84433 108723
Ensembl ENSG00000198286 ENSMUSG00000036526
UniProt Q9BXL7 Q8CIS0
RefSeq (mRNA) NM_032415 NM_175362
RefSeq (protein) NP_115791 NP_780571
Location (UCSC) Chr 7:
2.95 – 3.08 Mb
Chr 5:
140.87 – 141 Mb
PubMed search [1] [2]

Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein that in humans is encoded by the CARD11 gene.[1][2][3]

Function[edit]

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activates NF-kappaB and induces the phosphorylation of BCL10.[3]

Interactions[edit]

CARD11 has been shown to interact with BCL10.[4]

References[edit]

  1. ^ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J Biol Chem 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. 
  2. ^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195. 
  3. ^ a b "Entrez Gene: CARD11 caspase recruitment domain family, member 11". 
  4. ^ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. 

Further reading[edit]